Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate

Two new irreversible inhibitors of dihydrodipicolinate synthase, a key enzyme in lysine biosynthesis and an important antibiotic target, are reported.