کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10596903 981953 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities
چکیده انگلیسی
A simple 2-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of Plasmodium falciparum W2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 4, 15 February 2005, Pages 1015-1018
نویسندگان
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