Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

The C(2) 3,5-dichlorophenyl-, C(4) carboxyl-, C(5) alkyl-substituted oxazole derivatives synthesized in this study exhibit substantial transthyretin fibril formation inhibition activity in vitro and acceptable binding selectivity in human plasma making them appealing drug candidates against neuropathologies associated with transthyretin amyloidogenesis.