1,2,4-Benzothiadiazine derivatives as α1 and 5-HT1A receptor ligands

A series of 1,2,4-benzothiadiazine derivatives were synthesized and tested as selective ligands at α1-adrenergic and 5-HT1A receptor systems. Compound 1 has been characterized as a α1D-antagonist, while 6 as a 5-HT1A partial agonist.