7α,11β-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties

7α,11β-Dimethyl-19-nortestosterone, made by 1,6-methyl addition to 17β-acetoxy-11β-methylestra-4,6-dien-3-one, was a highly potent and selective androgen response modulator. It had enhanced androgen receptor binding, androgenic activity, and anabolic:androgenic ratio over its two monomethyl homologs.