QSAR studies on 1,2-dithiole-3-thiones: modeling of lipophilicity, quinone reductase specific activity, and production of growth hormone

Quantitative structure-activity relationship (QSAR) studies on lipophilicity (log P) for a series of 1,2-dithiole-3-thiones have been carried out using distance-based topological indices. In addition, we have also reported QSAR study on modeling quinone reductase specific activity (logCDQR) and production of growth hormone (logCDGH). The regression analysis of the data show that this set of compounds exhibit 'familial' relationships in that excellent results are obtained by dividing the data set into two classes (families).