Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1

2-Anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones are inhibitors of c-Src and Wee1 kinases. Selectivity for c-Src was not markedly changed by 6-phenyl ring substituents, but was lowered by 5-alkyl substituents.