Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives

The synthesis and evaluation of compound 4 (ES-2133) and its related optically active compounds as iNOS inhibitor is reported. In addition, an alternative synthetic method to the selected compound 4 and its pharmacokinetic profile is also reported.