Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT7 receptor

The synthesis of novel C6-aryl substituted derivatives of (S)-3-(dimethylamino)chroman is described. The novel derivatives display 5-HT7 receptor affinities that varies from nM to μM, indicating that this small set of derivatives constitute a novel and interesting starting point for further structure-serotonin 5-HT7 activity relationship (SAR) studies.