Preparation and properties of cyclic acetal based biodegradable gel by thiol-ene photopolymerization

► The cyclic acetal monomer EHDA was prepared by an easy method. ► The cyclic acetal based gels were prepared by thiol-ene photopolymerization. ► This gel could completely avoid acidic degradation products. ► This gel had non-toxicity to cell L-929 and had good biocompatibility.