Investigation on the effect of collagen and vitamins on biomimetic hydroxyapatite coating formation on titanium surfaces

► Hydroxyapatite was grown on Ti using a modified supersaturated calcification solution (M-SCS). ► Vitamins (A and D3) and collagen in M-SCS have a significant effect on apatite precipitation. ► M-SCS stimulates a biomimetic apatite deposition with 0.5-1 μm thickness in a short time. ► Hydroxyapatite crystallites have thin plate morphologies and size below 1 μm.