Novel glycerol crosslinked poly(methyl methacrylate) synthesized by chemo-enzymatic method for controlled release application

► One step polymerization of methyl methacrylate and its crosslinking with glycerol was performed in the presence of chemical initiator and Novozym 435. ► Nanoparticles of glycerol crosslinked PMMA were synthesized. ► Nanoparticles encapsulate and release DEET at a controlled rate.