An in-vitro study of the effects of temperature on breast cancer cells: Experiments and models

► An implantable device uses resistive heating to deliver localized hyperthermia. ► Controlled, cyclic hyperthermia is achieved using a biomedical device. ► Isothermal heating causes morphological, physical changes in the cell cytoskeleton. ► After 5 days of cyclic heat treatment, MDA-MB-231 cells undergo cell cycle arrest.