Controlled drug delivery from porous hydroxyapatite grafts: An experimental and theoretical approach

A numerical approach, based on the use of the Finite Element Method, was adopted to describe the drug release kinetics from the porous ceramic graft. Numerical results on drug release in phosphate buffer saline solution were compared with experimental data and a good agreement was found. The importance of FEM modelling emerges as a predictive tool to study HA graft drug release performances in an efficient way, also in complex set-ups like the one here selected.