کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10625733 989634 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and biocompatibility evaluation of sol-gel derived bioactive glass scaffolds prepared by freeze casting method
ترجمه فارسی عنوان
ارزیابی سنتز، مشخصه و سازگاری زیست سازگاری داربست های شیشه ای زیست فعال حاصل از سل ژل، تهیه شده با روش ریختن یخ
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد سرامیک و کامپوزیت
چکیده انگلیسی
In this study, a new class of bioactive glass scaffolds was prepared through freeze casting method for bone tissue engineering applications. After analyzing the structural characteristics of the scaffolds, in vitro biological evaluations were assessed through monitoring alkaline phosphatase (AP) activity of osteoblast cells and soaking in simulated body fluid (SBF) for different time intervals. It was shown that the scaffolds consisted of bioactive glass plates with interconnected pores between them, aligned along the ice growth direction. The ability of the scaffolds for supporting the growth of human fetal osteoblastic cells (hFOB 1.19) was approved. Moreover, inductively coupled plasma-atomic emission spectrometry (ICP-AES) showed meaningful compositional changes of calcium, phosphorus and silicon in SBF solution, indicating the apatite forming ability of the scaffolds. The present investigation revealed that freeze casting could be an effective method for the preparation of highly bioactive scaffolds. In addition, the scaffolds proved to be highly compatible for the proposed works in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ceramics International - Volume 40, Issue 4, May 2014, Pages 5349-5355
نویسندگان
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