Fabrication of mesoporous hydroxycarbonate apatite for oral delivery of poorly water-soluble drug carvedilol

► Mesoporous hydroxycarbonate (HCA) was synthesized using CaCO3 as a template. ► Poorly water-soluble drug carvedilol was selected as a model drug. ► Carvedilol loaded in mesoporous HCA was in an amorphous state. ► Mesoporous HCA had high drug load efficiency and provided fast release of carvedilol. ► HCA is a good carrier for the oral delivery of poorly water-soluble drugs.