کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1067050 948866 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High Drinking in the Dark Mice: A genetic model of drinking to intoxication
ترجمه فارسی عنوان
نوشیدن زیاد در موشهای تیره: یک مدل ژنتیکی از نوشیدن به مسمومیت
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

Drinking to intoxication is a critical component of risky drinking behaviors in humans, such as binge drinking. Previous rodent models of alcohol consumption largely failed to demonstrate that animals were patterning drinking in such a way as to experience intoxication. Therefore, few rodent models of binge-like drinking and no specifically genetic models were available to study possible predisposing genes. The High Drinking in the Dark (HDID) selective breeding project was started to help fill this void, with HDID mice selected for reaching high blood alcohol levels in a limited access procedure. HDID mice now represent a genetic model of drinking to intoxication and can be used to help answer questions regarding predisposition toward this trait as well as potential correlated responses. They should also prove useful for the eventual development of better therapeutic strategies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alcohol - Volume 48, Issue 3, May 2014, Pages 217–223
نویسندگان
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