کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1067592 948896 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens
چکیده انگلیسی

Chronic and excessive alcohol drinking lead to alcohol dependence and loss of control over alcohol consumption, with serious detrimental health consequences. Chronic alcohol exposure followed by protracted withdrawal causes profound alterations in the brain reward system that leads to marked changes in reinforcement mechanisms and motivational state. These long-lasting neuroadaptations are thought to contribute to the development of cravings and relapse. The nucleus accumbens (NAcc), a central component of the brain reward system, plays a critical role in alcohol-induced neuroadaptive changes underlying alcohol-seeking behaviors. Here we review the findings that chronic alcohol exposure produces long-lasting neuroadaptive changes in various ion channels that govern intrinsic membrane properties and neuronal excitability, as well as excitatory and inhibitory synaptic transmission in the NAcc that underlie alcohol-seeking behavior during protracted withdrawal.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alcohol - Volume 46, Issue 4, June 2012, Pages 317–327
نویسندگان
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