Keywords: نورون ستون فقرات متوسط; Chronic pain; Motivated behavior; Reward; Limbic system; Addiction; VTA; ventral tegmental area; SN; substantia nigra; PFC; prefrontal cortex; mPFC; medial prefrontal cortex; NAc; nucleus accumbens; BLA; basolateral amygdala; CeA; central amygdala; PBn; p
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Keywords: نورون ستون فقرات متوسط; Medium spiny neuron; Striatum; Stem cells; Cell model; Huntington disease; CRISPR/Cas9; Gene editing;
Keywords: نورون ستون فقرات متوسط; AC; adenylate cyclase; ADHD; attention deficit hyperactivity disorder; ACC; anterior cingulate cortex; ALS; amyotrophic lateral sclerosis; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATP; adenosine triphosphate; BBB; blood-brain barrier;
Keywords: نورون ستون فقرات متوسط; HD; Huntington disease; Htt; Huntingtin; MSN; medium spiny neuron; S1R; sigma-1 receptor; ER; endoplasmic reticulum; YAC128; yeast artificial chromosome 128Q expansion mice; 3-PPP; R(+)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride; SOC; store-oper
Keywords: نورون ستون فقرات متوسط; 6-OHDA; 6-hydroxydopamine; Aβ; amyloid-β; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; APOE4; apolipoprotein E4; APP; amyloid precursor protein; ASCL1; achaete-scute family basic helix-loop-helix transcription factor 1; ATP; adenosine trip
Keywords: نورون ستون فقرات متوسط; Conditioning; Nucleus accumbens; AMPA; Arp2/3; Cofilin; Actin; AMPAR; α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor; Arp2/3; actin-related protein 2/3; CS; conditioned stimulus; DA; dopamine; IP; intraperitoneal; LIMK; LIM-domain-containing
Keywords: نورون ستون فقرات متوسط; AMPA; 2-amino-3(3-hydroxy-5-methyl-isoxazol-4yl)propanoic acid; BNST; bed nucleus of the stria terminalis; CeA; central nucleus of the amgydala; CSF; cerebrospinal fluid; DLS; dorsolateral striatum; DMS; dorsomedial striatum; EC; external capsule; EPSP; e
Keywords: نورون ستون فقرات متوسط; AAV4; adeno-associated virus serotype 4; BDNF; brain-derived neurotrophic factor; bFGF; fibroblast growth factor 2; BME; β-mercaptoethanol; BMP; bone morphogenetic protein; Cas9; CRISPR associated protein 9; Cla; claustrum; CN; caudate nucleus; CRISPR; c
Keywords: نورون ستون فقرات متوسط; Alcohol; Addiction; Golgi; Medium spiny neuron; Structural plasticity
Keywords: نورون ستون فقرات متوسط; CI; cerebral ischemia; PD; Parkinson's disease; HD; Huntington's disease; SN; substancia nigra; DA; dopamine; GABA; gamma-aminobutyric acid; MSN; medium spiny neuron; CNS; central nervous system; NSC; neural stem cells; ES; embryonic stem; MSC; mesenchyma
Keywords: نورون ستون فقرات متوسط; 5-HT; serotonin/5-hydroxytryptamine; ACC; anterior cingulate cortex; ACh; acetylcholine; ADHD; attention deficit hyperactivity disorder; BG; basal ganglia; CBG; cortico-basal ganglia pathway; CNS; central nervous system; DA; dopamine; EMG; electromyograph
Extinction and Reinstatement of Cocaine-seeking in Self-administering Mice is Associated with Bidirectional AMPAR-mediated Plasticity in the Nucleus Accumbens Shell
Keywords: نورون ستون فقرات متوسط; ACSF; artificial cerebral spinal fluid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; COC; cocaine; CUE; cocaine-associated discrete cue light; D-AP5; D-aminophosphonovaleric acid; FR1; fixed ratio 1 schedule of reinforcement; GAB
Mechanisms of Neurofeedback: A Computation-theoretic Approach
Keywords: نورون ستون فقرات متوسط; ALIC; anterior limb of the internal capsule; BOLD; blood-oxygen-level-dependent; EEG; electroencephalography; MEG; magnetoencephalography; MSN; medium spiny neuron; PAF; peak alpha frequency; rt; real-time; SCP; slow cortical potential; UAF; upper alpha f
Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction
Keywords: نورون ستون فقرات متوسط; Addiction; Nucleus accumbens; Glutamate; Tetrapartite synapse; Synaptic plasticity; Metaplasticity; LTD; Long term depression; LTP; Long term potentiation; NAc; Nucleus accumbens; CPP; Conditioned place preference; SA; Self-administration; PFC; Prefrontal
Ionotropic and metabotropic glutamate receptors regulate protein translation in co-cultured nucleus accumbens and prefrontal cortex neurons
Keywords: نورون ستون فقرات متوسط; FUNCAT; Glutamate receptors; Medium spiny neuron; Nucleus accumbens; Prefrontal cortex; Protein translation;
ReviewEmerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression
Keywords: نورون ستون فقرات متوسط; Deep brain stimulation; Excitatory synaptic transmission; Medium spiny neuron; Social defeat; Stress; Striatum;
Suppressive regulation of lateral inhibition between medium spiny neurons via dopamine D1 receptors in the rat nucleus accumbens shell
Keywords: نورون ستون فقرات متوسط; uIPSC; unitary inhibitory postsynaptic current; NAc; nucleus accumbens; MSN; medium spiny neuron; VTA; ventral tegmental area; Nucleus accumbens shell; Lateral inhibition; Unitary IPSC; Dopamine; SKF82958;
Modeling Huntington׳s disease with patient-derived neurons
Keywords: نورون ستون فقرات متوسط; (HD); Huntington׳s disease; (HTT); Huntingtin; (mtHTT); mutant Huntingtin; (polyQs); polyglutamine repeats; (CNS); central nervous system; (hESC); human embryonic stem cell; (hiPSC); human induced pluripotent stem cell; (polyQs); polyglutamine repeats; (
The phosphodiesterase 10A selective inhibitor, TAK-063, induces c-Fos expression in both direct and indirect pathway medium spiny neurons and sub-regions of the medial prefrontal cortex in rats
Keywords: نورون ستون فقرات متوسط; ACC; anterior cingulate cortex; AI; anterior insular cortex; BOLD; blood oxygenation level dependent; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; dlPFC; dorsolateral prefrontal cortex; dmCpu; dorsomedial caudate-putamen; DP
Neural mechanisms of the nucleus accumbens circuit in reward and aversive learning
Keywords: نورون ستون فقرات متوسط; NAc; nucleus accumbens; GPi; globus pallidus interna; GPe; globus pallidus externa; VP; ventral pallidum; STN; subthalamic nucleus; SNr; substantia nigra pars reticulate; SNc; substantia nigra pars compacta; VTA; ventral tegmental area; MSN; medium spiny
Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease
Keywords: نورون ستون فقرات متوسط; Medium spiny neuron; Whole-cell patch-clamp; Homeostatic scaling; Dendritic spine; Huntington's disease; AMPAR;
Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum
Keywords: نورون ستون فقرات متوسط; Basal ganglia; Schizophrenia; Parkinson's disease; Huntington's disease; ANOVA; Analysis of Variance; BAC; bacterial artificial chromosome; c-Fos(+); c-Fos immunopositive nuclei; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate;
Differential CaMKII regulation by voltage-gated calcium channels in the striatum
Keywords: نورون ستون فقرات متوسط; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CaMKII; calcium/calmodulin-dependent protein kinase II; LTCC; L-type calcium channel; MSN; medium spiny neuron; RTCC; R-type calcium channel; TTCC; T-type calcium channel; VGCC; voltag
Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease
Keywords: نورون ستون فقرات متوسط; 6-OHDA; 6-hydroxydopamine; aCSF; artificial cerebrospinal fluid; MSN; medium spiny neuron; NMDAR; N-methyl-d-aspartate receptor; s/m EPSC; spontaneous/miniature excitatory postsynaptic current; sIPSC; spontaneous inhibitory postsynaptic current; TH; tyros
Phosphodiesterase 10A inhibitor MP-10 effects in primates: Comparison with risperidone and mechanistic implications
Keywords: نورون ستون فقرات متوسط; PDE10A inhibitors; Phosphodiesterase; Schizophrenia; Striatum; D2 receptors; Medium spiny neuron;
L-DOPA Treatment Selectively Restores Spine Density in Dopamine Receptor D2–Expressing Projection Neurons in Dyskinetic Mice
Keywords: نورون ستون فقرات متوسط; Behavioral sensitization; dyskinesia; L-DOPA; medium spiny neuron; Parkinson’s disease; striatum; three-dimensional neuronal reconstruction
Acute nigro-striatal blockade alters cortico-striatal encoding: An in vivo electrophysiological study
Keywords: نورون ستون فقرات متوسط; PD; Parkinson's disease; BG; basal ganglia; DA; dopamine; MFB; medial forebrain bundle; TTX; tetrodotoxin; ECoG; electrocorticogram; SWA; slow wave activity; SNr; substantia nigra pars reticulate; STN; nucleus subthalamicus; SNc; substantia nigra pars com
Deconstructing the neural and ionic involvement of seizure-like events in the striatal network
Keywords: نورون ستون فقرات متوسط; Basal ganglia; Striatum; Medium spiny neuron; Seizures; Epilepsy; In vitro;
Acute binge pattern cocaine administration induces region-specific effects in D1-r- and D2-r-expressing cells in eGFP transgenic mice
Keywords: نورون ستون فقرات متوسط; ANOVA; analysis of variance; BAC; bacterial artificial chromosome; D1-r; D1-receptor; D2-r; D2-receptor; DL; dorsolateral; eGFP; enhanced green fluorescent protein; MSN; medium spiny neuron; NAc; nucleus accumbens; PFA; paraformaldehyde; SN; substantia ni
ReviewOptogenetic insights into striatal function and behavior
Keywords: نورون ستون فقرات متوسط; Dstr; dorsal striatum; NAc; nucleus accumbens; MSN; medium spiny neuron; TAN; tonically active cholinergic interneuron; FS; fast spiking interneuron; LTS; low threshold spiking interneuron; SN; substantia nigra; VTA; ventral tegmental area; Optogenetics;
Advances in thin tissue Golgi-Cox impregnation: Fast, reliable methods for multi-assay analyses in rodent and non-human primate brain
Keywords: نورون ستون فقرات متوسط; 3-D; 3-dimensional; 6-OHDA; 6-hydroxydopamine; ABC; avidin biotin peroxidase complex; BrdU; bromodeoxyuridine; DA; dopamine; D1R; dopamine D1 receptor; D2R; dopamine D2 receptor; DAB; 3,3â²-diaminobenzidine tetrahydrochloride; DMSO; dimethyl sulfoxide; E
Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats
Keywords: نورون ستون فقرات متوسط; AcbC; nucleus accumbens, core subregion; bHR; selectively bred high-responder rats; bLR; selectively bred low-responder rats; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethylindocarbocyanine perchlorate (lipophilic dye); MSN; medium spiny neuron; mTORC1;
DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowth
Keywords: نورون ستون فقرات متوسط; DJ-1; β-Tubulin III; HIF-1α; Parkinson's disease; Microtubule dynamics; Striatum; Medium spiny neuron; Dendritic spine; Neurite outgrowth
GABAA receptor mediated inhibition contributes to corticostriatal frequency filtering
Keywords: نورون ستون فقرات متوسط; Lowpass filter; Corticostriatal plasticity; Medium spiny neuron; GABAA receptors;
Striatal gating through up states and oscillations in the basal ganglia: Implications for Parkinson’s disease
Keywords: نورون ستون فقرات متوسط; Basal ganglia; Medium spiny neuron; Globus pallidus; Oscillations; Parkinson’s disease
Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion
Keywords: نورون ستون فقرات متوسط; Adenosine; Dopamine; A2a; D2; Cholinergic interneuron; Medium spiny neuron; Striatopallidal; Patch clamp; Two photon laser scanning microscopy; Spine; Parkinson's disease;
Novel triazines as potent and selective phosphodiesterase 10A inhibitors
Keywords: نورون ستون فقرات متوسط; PDE10A; phosphodiesterase 10A; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanine monophosphate; MSN; medium spiny neuron; MK-801; dizocilpine maleate; MED; minimal effective dose; PDE; cyclic nucleotide phosphodiesterase; LMA; locomotor activity;
Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens
Keywords: نورون ستون فقرات متوسط; Alcoholism; Nucleus accumbens; Medium spiny neuron; Glutamate; GABA
Brain stimulation reward is altered by affecting dopamine-glutamate interactions in the central extended amygdala
Keywords: نورون ستون فقرات متوسط; BSR; brain stimulation reward; cAMP; cyclic adenosine monophosphate; MFB; medial forebrain bundle; MSN; medium spiny neuron; NAc; nucleus accumbens; NBQX; 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide; PKA; protein kinase A; SLEAc
Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission
Keywords: نورون ستون فقرات متوسط; Serotonin; Striatum; Medium spiny neuron; Cortex; EPSC; Electrophysiology; ST1936
Investigating striatal function through cell-type-specific manipulations
Keywords: نورون ستون فقرات متوسط; striatum; BAC transgenic; optogenetics; medium spiny neuron; cholinergic interneuron; fast-spiking interneuronBG, basal ganglia; ChR2, channelrhodopsin-2; CPP, conditioned place preference; FSI, fast-spiking interneurons; MSN, medium spiny projection neur
Multiscale imaging characterization of dopamine transporter knockout mice reveals regional alterations in spine density of medium spiny neurons
Keywords: نورون ستون فقرات متوسط; Electron tomography; Striatum; Bioinformatics; Medium spiny neuron; Morphometric analysis; Spine density; Cell centered database
Gender and manganese exposure interactions on mouse striatal neuron morphology
Keywords: نورون ستون فقرات متوسط; Manganese; Gender; Medium spiny neuron; Neuron morphology;
Subsets of spiny striosomal striatal neurons revealed in the Gad1-GFP BAC transgenic mouse
Keywords: نورون ستون فقرات متوسط; Basal Ganglia; Patch; GABA; Medium spiny neuron; BAC transgenic
Sex differences and effects of cocaine on excitatory synapses in the nucleus accumbens
Keywords: نورون ستون فقرات متوسط; Addiction; Medium spiny neuron; Psychostimulants; Dendritic spine; Sensitization; Sex difference
Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperAltered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease
Keywords: نورون ستون فقرات متوسط; HVA calcium channels; medium spiny neuron; 6-hydroxydopamine; reserpine; DJ-1; PINK1; CN; cell capacitance; HBSS; Hank's balanced salt solution; HVA; high voltage-activated; MSNs; medium spiny neurons; PD; Parkinson's disease; PINK1; PTEN induced kinase 1
Excitability range of medium spiny neurons widens through the combined effects of inward rectifying potassium current inactivation and dopaminergic modulation
Keywords: نورون ستون فقرات متوسط; Nucleus accumbens; Medium spiny neuron; Inward rectifying potassium current; Inactivation; Dopamine; Excitability
Developmental regulation and neuroprotective effects of striatal tonic GABAA currents
Keywords: نورون ستون فقرات متوسط; medium spiny neuron; excitotoxicity; Huntington's disease; cell swelling; delta subunitaCAF, artificial cerebro spinal fluid; AP-5, d-2-amino-5-phosphonovalerate; BMI, bicuculline methiodide; DNQX, 6,7-Dinitroquinoxaline-2,3-dione; D1, dopamine receptor t
Combination of diOlistic labeling with retrograde tract tracing and immunohistochemistry
Keywords: نورون ستون فقرات متوسط; FLMs; fluorescent latex microspheres; FG; fluorogold; ir; immunoreactive; MSN; medium spiny neuron; TH; tyrosine hydroxylase; VGluT1; vesicular glutamate transporter 1; TBS; Tris-buffered saline; Ballistic; Dendritic spine; DiI; DiOlistic labeling; Dual l
Is the loss of thalamostriatal neurons protective in parkinsonism?
Keywords: نورون ستون فقرات متوسط; Cerebellin1; Dendritic spine; Dopamine; Medium spiny neuron; Parkinson's disease; Parafascicular nucleus; Thalamus