کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8840618 | 1614692 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extinction and Reinstatement of Cocaine-seeking in Self-administering Mice is Associated with Bidirectional AMPAR-mediated Plasticity in the Nucleus Accumbens Shell
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کلمات کلیدی
NAcShFR1AMPARaCSFmEPSCPPRCOCNMDARMSNd-AP5 - D-AP5SAL - WILLα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor - α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptorgamma-aminobutyric acid - اسید گاما آمینو بوتیریکself-administration - خود ادارهSaline - سالینrelapse - عود یا بازگشت بیماریartificial cerebral spinal fluid - مایع مغزی نخاعی مغزیpaired pulse ratio - نسبت پالس زوجیCue - نشانهmedium spiny neuron - نورون ستون فقرات متوسطNucleus accumbens - هسته accumbensnucleus accumbens shell - هسته accumbens پوستهinternational units - واحدهای بین المللیPlasticity - پلاستیکCocaine - کوکائین GABA - گاباN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartateyohimbine - یوهیمبین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Extinction and Reinstatement of Cocaine-seeking in Self-administering Mice is Associated with Bidirectional AMPAR-mediated Plasticity in the Nucleus Accumbens Shell Extinction and Reinstatement of Cocaine-seeking in Self-administering Mice is Associated with Bidirectional AMPAR-mediated Plasticity in the Nucleus Accumbens Shell](/preview/png/8840618.png)
چکیده انگلیسی
Experience-dependent synaptic plasticity is an important component of both learning and motivational disturbances found in addicted individuals. Here, we investigated the role of cocaine experience-dependent plasticity at excitatory synapses in the nucleus accumbens shell (NAcSh) in relapse-related behavior in mice with a history of volitional cocaine self-administration. Using an extinction/reinstatement paradigm of cocaine-seeking behavior, we demonstrate that cocaine-experienced mice with extinguished cocaine-seeking behavior show potentiation of synaptic strength at excitatory inputs onto NAcSh medium spiny neurons (MSNs). Conversely, we found that exposure to various distinct types of reinstating stimuli (cocaine, cocaine-associated cues, yohimbine “stress”) after extinction can produce a relative depotentiation of NAcSh synapses that is strongly associated with the magnitude of cocaine-seeking behavior exhibited in response to these challenges. Furthermore, we show that these effects are due to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-specific mechanisms that differ depending on the nature and context of the reinstatement-inducing stimuli. Together, our findings identify common themes as well as differential mechanisms that are likely important for the ability of diverse environmental stimuli to drive relapse to addictive-like cocaine-seeking behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 384, 1 August 2018, Pages 340-349
Journal: Neuroscience - Volume 384, 1 August 2018, Pages 340-349
نویسندگان
Stephanie R. Ebner, Erin B. Larson, Matthew C. Hearing, Anna E. Ingebretson, Mark J. Thomas,