Deconstructing the neural and ionic involvement of seizure-like events in the striatal network

► Chemostimulants induced striatal seizures in immature rat brain slices in vitro. ► Striatal seizures synchronized with medium spiny neuron hyperexcitability. ► Striatal hyperexcitability is developmentally regulated. ► Striatal hyperexcitability requires NMDAR activation. ► Seizure-like events can form in the isolated striatum.