کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1067860 948937 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics
چکیده انگلیسی

A published logistic regression model based on the Canadian Acetaminophen Overdose Study registry was used to calculate the risk of hepatotoxicity after an acute acetaminophen overdose and to estimate a treatment threshold line for alcoholic patients who did not co-ingest alcohol (i.e., abstinent alcoholics) on the Rumack–Matthew nomogram. The risk of hepatotoxicity in nonalcoholic and abstinent alcoholic patients was calculated at the acetaminophen concentration of 150 μg/ml at 4 h (37.5 μg/ml at 12 h) treatment threshold line. This corresponds to the “possible risk” line on the Rumack–Matthew nomogram and represents a 1.6% risk of hepatotoxicity for nonalcoholic patients at or below this line. At or below this same 150 μg/ml at 4-h line, abstinent alcoholic patients have a hepatotoxicity risk of 10.7%. The risk of hepatotoxicity in abstinent alcoholics' equivalent to that of nonalcoholics (i.e., 1.6%) occurs at a lower acetaminophen concentrations treatment threshold line, that is, 104 μg/ml at 4 h (26 μg/ml at 12 h). Because of difficulties plotting this new line on the familiar Rumack–Matthew semilogarithmic scale, a line connecting 100 μg/ml at 4 h (25 μg/ml at 12 h) is proposed. This line equates to a 1.1% risk of hepatotoxicity in abstinent alcoholic patients. The analysis supports the observation that based on the published model abstinent alcoholics might have a greater risk of hepatotoxicity after an acute acetaminophen overdose. This proposed new risk line can be used in hypothesis generation for future clinical studies in this alcohol related problem.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alcohol - Volume 42, Issue 3, May 2008, Pages 213–218
نویسندگان
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