کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1069993 | 1486163 | 2013 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A family history of substance dependence obscures the group differences in brain function associated with HIV-1 and ART A family history of substance dependence obscures the group differences in brain function associated with HIV-1 and ART](/preview/png/1069993.png)
BackgroundRecently, the NIH called for additional research on the topic of viral and host factors contributing to impaired cognitive and neural function in HIV/AIDS patients and their response to antiretroviral treatment. This investigation responds to that call by examining a host factor, a family history of substance dependence, often overlooked in cognitive and neuroimaging studies of HIV/AIDS.MethodsWe categorized 146 HIV-1 seropositive patients receiving antiretroviral treatment (ART) and 92 seronegative volunteers by the presence or absence of alcohol, cocaine, or heroin dependence affecting a biological parent. Seropositive patients were further categorized by the estimated ability of their individual ART regimens to penetrate the CNS. The indicator of brain function was a 3–7 Hz oscillatory electroencephalographic response (theta ERO) evoked by target stimuli presented during a simple selective attention task.ResultsThe analysis revealed that the presence of a family history of substance dependence obscured the reduction in frontal theta ERO power accompanying the presence of HIV-1 as well as the improvement in frontal theta ERO power accompanying treatment with ART agents estimated to have greater (n = 41) versus lesser (n = 105) CNS penetrance. Secondary analyses employing sLORETA source localization techniques revealed that the source of the theta ERO response was similarly reduced by the presence of either HIV-1 or a family history of substance dependence.ConclusionsWe conclude that a family history of substance dependence complicates and obscures the subtle neurophysiological changes which typically accompany HIV/AIDS and ART. Studies of new therapeutic agents for HIV-1-associated cognitive and neurophysiological impairments must consider this complication and exclude or control it.
Journal: Drug and Alcohol Dependence - Volume 127, Issues 1–3, 1 January 2013, Pages 45–52