Synthesis of SPIO-chitosan microspheres for MRI-detectable embolotherapy

Spherical SPIO nanoparticles were synthesized and embedded in polyglucosamine (chitosan) by a sonochemical method. The embedded microspheres were shifted out in the range of 100-150 μm. The microspheres were injected into the kidney of a New Zealand white rabbit via an angiographic catheter, and detected in magnetic resonance images of the kidney.