کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10729721 1042080 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation of the hypoxia imaging PET tracer [18F]FAZA: reaction parameters and automation
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Preparation of the hypoxia imaging PET tracer [18F]FAZA: reaction parameters and automation
چکیده انگلیسی
18F-labeling of the nitroimidazole nucleoside analogue 1-(5-fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole (FAZA) was developed to use this tracer in PET for detection of hypoxia. Parameters for labeling and hydrolysis were optimized with regard to amount of precursor, temperature and time. Labeling yields reached a maximum of 62±4% at 100 °C within 5 min using 5 mg of precursor. Hydrolysis was best performed with 1 mL of 0.1 N NaOH at 20 °C for 2 min. Transfer of these conditions to an automated synthesizer resulted in an overall radiochemical yield of 20.7±3.5%. Absolute yields at EOS were 9.8±2.3 GBq of [18F]FAZA ready for injection (n=21; 50 min after EOB; irradiation parameters: 35 μA, 60 min). Thus, a convenient approach suitable for large-scale production of [18F]FAZA was developed by an automated process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 62, Issue 6, June 2005, Pages 897-901
نویسندگان
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