کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10729739 | 1042085 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis procedure for routine production of [carbonyl-11C]desmethyl-WAY-100635
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis procedure for routine production of [carbonyl-11C]desmethyl-WAY-100635 Synthesis procedure for routine production of [carbonyl-11C]desmethyl-WAY-100635](/preview/png/10729739.png)
چکیده انگلیسی
An improved one-pot synthesis procedure for routine production of [carbonyl-11C]desmethyl-WAY-100635 ([11C]DWAY) is described. An efficient purification of the crude product has also been developed and was accomplished by C-18 reversed-phase semi-preparative HPLC using 55/45 EtOH-NaH2PO4 buffer (20 mM, pH=6.5) as the eluent. The desired product fraction was collected in a 2.0-2.5 mL volume and formulated with 11 mL of 0.9% saline. The radioligand was ready for human use in 45 min (EOB). The product was obtained with a radiochemical yield of 11.1±1.8% (EOB, n=15) with a radiochemical purity of >99%. Specific activity was 133.2-185.0 GBq/μmol (3.6-5.0 Ci/μmol, EOS, n=2) when ca. 37.0 GBq (ca. 1.0 Ci) of starting [11C]CO2 was used. Unlabeled mass of [11C]DWAY was found to be 0.15-0.24 μg/mL and the precursor was present in less than 50 ng/mL in final production solution.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 62, Issue 5, May 2005, Pages 721-727
Journal: Applied Radiation and Isotopes - Volume 62, Issue 5, May 2005, Pages 721-727
نویسندگان
Dilip K. Maiti, Pulak K. Chakraborty, Diane C. Chugani, Otto Muzik, Thomas. J. Mangner, Harry T. Chugani,