کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10729813 | 1042098 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New aspects on the preparation of [11C]Methionine-a simple and fast online approach without preparative HPLC
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: New aspects on the preparation of [11C]Methionine-a simple and fast online approach without preparative HPLC New aspects on the preparation of [11C]Methionine-a simple and fast online approach without preparative HPLC](/preview/png/10729813.png)
چکیده انگلیسی
At present, most data available on PET imaging of brain tumors using amino acids are based on l-[S-methyl-11C]methionine (MET). This radiopharmaceutical accurately delineates tumor extent, sometimes even better than CT. Since MET is playing such an important role for PET, a potent preparation method for this radiotracer allowing frequent syntheses for PET routine is desirable. Therefore, a simple disposable synthesis module was conceived without HPLC purification. Using a solid supported [11C]methylation on Al2O3 leads to the simplification of the preparation requiring only filtration for separation of precursor and MET. The presented method is able to produce high purity MET in excellent yields enough to serve several consecutive patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 62, Issue 3, March 2005, Pages 441-445
Journal: Applied Radiation and Isotopes - Volume 62, Issue 3, March 2005, Pages 441-445
نویسندگان
Markus Mitterhauser, Wolfgang Wadsak, Andreas Krcal, Joern Schmaljohann, Harald Eidherr, Alexander Schmid, Helmut Viernstein, Robert Dudczak, Kurt Kletter,