99mTc Nanocoll: A radiopharmaceutical for sentinel node localisation in breast cancer-In vitro and in vivo results

This study evaluated labelling efficiency and radiochemical purity of 99mTc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of 99mTc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2 h eluate in vacuum or nitrogen. Labelling 26 MBq/μg 99mTc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.