Automation of labelling of Lipiodol with high-activity generator-produced 188Re

This work describes optimisation of the kit formulation for labelling of Lipiodol with high-activity generator-produced rhenium-188. Radiochemical purity (RCP) was 92.52±2.3% and extraction yield was 98.56±1.2%. The synthesis has been automated with a TADDEO module (Comecer) giving a mean final yield of 52.68±9.6%, and reducing radiation burden to the radiochemist by 80%. Radiolabelled Lipiodol (188Re-SSS/Lipiodol) is stable for at least 7 days (RCP=91.07±0.9%).