A breach in the scaffold: The possible role of cytoskeleton dysfunction in the pathogenesis of major depression

► Not only actin, microtubules can also maintain dendrite and dendritic spine function. ► We summarize the significance of posttranslational modification of cytoskeleton. ► We summarize different modes of posttranslational modification of cytoskeleton. ► Abnormality of cytoskeletal posttranslational modification can occur in depression.