کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10736627 1045728 2013 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic mechanisms in Alzheimer's disease: Implications for pathogenesis and therapy
ترجمه فارسی عنوان
مکانیزم های اپیزیونیک در بیماری آلزایمر: پیامدهای پاتوژنز و درمان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
The vast majority of Alzheimer's disease (AD) are late-onset forms (LOAD) likely due to the interplay of environmental influences and individual genetic susceptibility. Epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNAs, constitute dynamic intracellular processes for translating environmental stimuli into modifications in gene expression. Over the past decade it has become increasingly clear that epigenetic mechanisms play a pivotal role in aging the pathogenesis of AD. Here, we provide a review of the major mechanisms for epigenetic modification and how they are reportedly altered in aging and AD. Moreover, we also consider how aberrant epigenetic modifications may lead to AD pathogenesis, and we review the therapeutic potential of epigenetic treatments for AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 12, Issue 4, September 2013, Pages 1024-1041
نویسندگان
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