AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

► AMPK regulates energy metabolic homeostasis and cell survival during stress. ► AMPK coordinates signaling of many age-related transcription factor pathways. ► Responsiveness of AMPK activation declines with aging. ► Increased AMPK activity extends the lifespan of lower organisms. ► It seems that AMPK signaling is a crucial regulator of healthspan and lifespan.