Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae

► DR delays the reduction in replicative lifespan associated with chronological age. ► MMP during chronological aging predicts subsequent replicative lifespan. ► Chronologically aged cells with highest MMP cannot complete a cell division. ► Chronologically aged cells with lowest MMP maintain a full replicative lifespan.