Aging-dependent brain electrophysiological effects in rats after distinct lactation conditions, and treadmill exercise: A spreading depression analysis

► We explored brain effects of lactation conditions and exercise in aged rats. ► We correlated cortical spreading depression (CSD) features with the factors studied. ► CSD was facilitated by unfavorable lactation, and impaired by exercise and aging. ► Data are clinically relevant as CSD is related to diseases like migraine and epilepsy.