C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction

► Degeneration of neuromuscular junction leading to sarcopenia is an agrin-dependent process. ► Serum C-Terminal Agrin Fragment identifies a subgroup of sarcopenic patients. ► Vitamin D supplementation and physical exercise seem to have a protective effect on the neuromuscular junctions.