Regulation of Drosophila lifespan by JNK signaling

► JNK signaling is a conserved regulator of lifespan. ► Multiple physiological processes are controlled by JNK to influence lifespan. ► JNK promotes oxidative stress tolerance and regulates apoptosis. ► Antagonism between JNK and insulin signaling influences metabolic homeostasis and lifespan. ► Excessive JNK activity negatively influences lifespan by disrupting intestinal regeneration.