Heat shock proteins and Drosophila aging

►Review of the expression and function of hsps in response to stress and aging. ►The role of the HSF pathway and the JNK/Foxo pathway. ►Antagonistic pleiotropy, sexual antagonistic pleiotropy, p53 and foxo. ►Protein turnover, proteotoxicity, and the role of hsps in aging. ►Hsps as predictive biomarkers of aging and life span.