Honeybee trophocytes and fat cells as target cells for cellular senescence studies

►Trophocytes and fat cells are distributed around the abdominal segments in honeybees. These cells may be used to study cellular senescence due to easy manipulation and isolation, large quantities, and convenience for drug screening. Trophocytes and fat cells are immersed in body fluid and can be used to test anti-aging drugs when drugs are microinjected into the body fluid. In a sense, honeybees can be used as an animated biomicroincubator. In this study, we demonstrated that the expression of age-related molecules in trophocytes and fat cells is associated with the senescence of the cells and that honeybee trophocytes and fat cells can serve as a model for the study of cellular senescence.