Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism

► Visceral adiposity and insulin resistance are common in aldosteronism patients. ► We report the effects of heme oxygenase (HO) on visceral adiposity in DOCA rats. ► The DOCA rat is a model of human aldosteronism. HO was enhanced by heme arginate (HA). ► HA suppressed visceral adiposity and inflammation and enhanced insulin sensitivity. ► The effects of HO on NF-κB, JNK, MCP-1, and ICAM-1 in visceral adiposity are novel.