Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells

► Stable HO-1 expression in nonerythroid cells does not decrease cellular heme. ► In such cells iron trafficking into mitochondria and heme synthesis are increased. ► Iron-regulatory protein activities and ferritin protein levels are lower owing to increased degradation. ► Stable HO-1 expression is associated with elevated cytosolic and mitochondrial O2−
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