Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells

► Glutathione protects HD striatal cells from caspase-3 activation and ROS formation. ► Glutathione synthesis is decreased in HD striatal cells. ► Intracellular glutathione levels are increased in mutant striatal cells. ► Decreased Mrp1 contributes to increased intracellular glutathione in HD cells.