P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice

► Establishes a free radical-based mechanistic model for nonalcoholic steatohepatitis. ► Purinergic receptor 7 (P2X7) triggers NADPH oxidase in Kupffer cells. ► P2X7 receptor-NADPH axis exacerbates NASH of obesity.