Manganese Porphyrin, MnTE-2-PyP5Â +, Acts as a Pro-Oxidant to Potentiate Glucocorticoid-Induced Apoptosis in Lymphoma Cells

► MnTE-2-PyP5 + enhances dexamethasone-induced apoptosis in lymphoma. ► MnTE-2-PyP5 + acts as a pro-oxidant. ► MnTE-2-PyP5 + depletes glutathione and glutathionylates proteins. ► MnTE-2-PyP5 + glutathionylates and inhibits NF-κB to enhance apoptosis. ► Glutathione is essential for MnTE-2-PyP5 + activity.