Resveratrol potentiates cytochrome P450 2Â d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse

► An association between CYP2D6 gene and Parkinson's disease (PD) is well known. ► Cyp2d22 is a mouse ortholog of human CYP2D6. ► Cyp2d22 neuroprotects against maneb- and paraquat (pesticides)-induced PD phenotype. ► Resveratrol inflects Cyp2d22-mediated neuroprotection.