Glucocorticoids inhibit lipopolysaccharide-mediated inflammatory response by downregulating microRNA-155: a novel anti-inflammation mechanism

► Glucocorticoids (GCs) inhibit miR-155 expression in LPS-induced inflammatory response in a GC receptor- and NF-κB-dependent manner. ► Downregulation of miR-155 contributes to the anti-inflammatory effect of GCs. ► Combining GC treatment and miR-155 inhibition enhances GC's anti-inflammatory effect in LPS-stimulated RAW264.7 cells.