β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner

► β-Caryophyllene (BCP) is a constituent of many essential oils of spice/food plants. ► Cisplatin (CIS) is a widely used anticancer drug that induces nephrotoxicity. ► CIS nephrotoxicity involves oxidative stress and the inflammatory response. ► BCP attenuates CIS-induced kidney inflammation, oxidative stress, and injury ► The protective effect of BCP is mediated via cannabinoid 2 receptors