کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10739024 | 1046853 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mildly oxidized low-density lipoprotein inhibits the in vitro induction of the specific antibody response to Candida albicans
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کلمات کلیدی
nLDLTBARSIL-1βFCSREMMoAbAb, antibody - Ab، آنتی بادیOxidized LDL - LDL اکسید شدهNative LDL - LDL بومیMonoclonal antibody - آنتی بادی مونوکلونالimmunoglobulin - ایمونوگلوبولینinterleukin - اینترلوکینrelative electrophoretic mobility - تحرک الکتروفورز نسبیFree radicals - رادیکال آزادfetal calf serum - سرم گوساله جنینHuman B cells - سلول های بنیادی انسانLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)Thiobarbituric reactive substances - واکنش پذیری تیوباربیتوریک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mildly oxidized low-density lipoprotein inhibits the in vitro induction of the specific antibody response to Candida albicans Mildly oxidized low-density lipoprotein inhibits the in vitro induction of the specific antibody response to Candida albicans](/preview/png/10739024.png)
چکیده انگلیسی
Oxidized low-density lipoprotein plays a critical role in the pathogenesis of atherosclerosis and exerts pleiotropic effects on various cellular functions. The present study was designed to evaluate the effects of mildly oxidized LDL (mLDL) on the induction and regulation of an in vitro specific antibody response. We found that mLDL significantly inhibited the induction of the anti-Candida albicans antibody response by human peripheral blood mononuclear cells (PBMC). mLDL-induced down-regulation of antibody production was abrogated by blocking the major receptors that bind and internalize modified LDL. In the mLDL-treated C. albicans-stimulated PBMC cultures an early increase in IL-1β production was observed and the addition of anti-IL-1β antibody abrogated the mLDL-induced inhibitory effect. Moreover, the addition of IL-1β to the cultures inhibited the induction of the specific antibody response, similar to mLDL. On the other hand, mLDL up-regulated PWM-induced polyclonal immunoglobulin (Ig) production. In the same cultures IgM anti-mLDL was found. These results indicate that the up-regulation of IL-1β production induced by mLDL may be involved in the hindering of B cell function, i.e., specific antibody production. This could be relevant in the pathogenesis of inflammatory diseases such as atherosclerosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 39, Issue 7, 1 October 2005, Pages 960-969
Journal: Free Radical Biology and Medicine - Volume 39, Issue 7, 1 October 2005, Pages 960-969
نویسندگان
Luciana Giordani, Benedetta Mattioli, Maria Giovanna Quaranta, Elena Giacomini, Irene Libri, Rosaria Varì, Roberta Masella, Marina Viora,