کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10739383 | 1046873 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease
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کلمات کلیدی
Oxidatively modified LDLRCAACSCHDoxLDLLCXOxidized LDL - LDL اکسید شدهantibodies - آنتی بادی هاMyocardial infarction - آنفارکتوس میوکاردcoronary heart disease - بیماری عروق کرونر قلبCoronary disease - بیماری های عروق کرونریFree radicals - رادیکال آزادAcute coronary syndrome - سندرم کرونری حادleft main coronary artery - شریان اصلی عروق کرونر سمت چپright coronary artery - شریان کرونر راستleft circumflex coronary artery - عروق کرونر چپ چپLAD - لادوC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی left anterior descending coronary artery - چپ قدامی نزولی عروق کرونر
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Autoantibodies against oxidized low-density lipoprotein (oxLDL) predict the progression of atherosclerosis. Several studies have shown that oxLDL is present in atherosclerotic lesions and that several factors present in active atherosclerotic plaques can oxidatively modify LDL. Oxidation of LDL induces production of autoantibodies against oxLDL (oxLDLab) that can be measured using an EIA test. Our aim was to see whether oxLDLab are associated with severe chest pain attacks in coronary heart disease (CHD) patients. Patients having two- or three-vessel CHD, as assessed by coronary angiography, and their siblings were recruited into the study (n = 568, mean age 55.8 years, range 29.3-83.2 years). Nondiabetic patients having a history of severe chest pain attacks had significantly higher oxLDLab levels (0.611 ± 0.56) than those who did not have a history of severe chest pain attacks (0.487 ± 0.40) (p = 0.027), even though age, cholesterol level, body mass index, and blood pressure were similar in both groups. However, no difference was found in oxLDLab levels in diabetic patients with or without a history of severe chest pain attacks. Increased levels of oxLDL autoantibodies are associated with severe chest pain attacks in nondiabetic patients with CHD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 39, Issue 12, 15 December 2005, Pages 1660-1665
Journal: Free Radical Biology and Medicine - Volume 39, Issue 12, 15 December 2005, Pages 1660-1665
نویسندگان
Jukka S. Luoma, Anu Kareinen, Outi Närvänen, Laura Viitanen, Markku Laakso, Seppo Ylä-Herttuala,