کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10739544 1046879 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mice transgenic for Alzheimer disease β-amyloid develop lens cataracts that are rescued by antioxidant treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Mice transgenic for Alzheimer disease β-amyloid develop lens cataracts that are rescued by antioxidant treatment
چکیده انگلیسی
Alzheimer disease is characterized by cerebral Aβ deposition, which we have recently discovered occurs also in the lens as cataracts in Alzheimer disease patients. Here we report the presence of significantly increased cataracts in the lenses of an Aβ-transgenic mouse model for Alzheimer disease and their amelioration upon treatment with EUK-189, a synthetic SOD/catalase mimetic. These data support an oxidative etiology for AD-associated lens cataracts and their potential to be treated preventatively with antioxidants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 38, Issue 2, 15 January 2005, Pages 258-261
نویسندگان
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