Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis

- Aging and inflammation contribute to the development and progression of arthritic and musculoskeletal diseases.
- “Inflammaging” refers to low-grade inflammation that occurs during physiological aging.
- “Chondrosenescence” refers to the age-dependent deterioration of chondrocyte function and is intimately linked with inflammaging.
- A better understanding of chondrosenescence may lead to the development of new therapeutic and preventive strategies for osteoarthritis.